Anaesthesia Blueprints Notes | Learning | Anaesthesia Residency | Millers Notes | Induction Agents
Thiopentone ( Ref - Millers book of anaesthesia) Uses and Dosage • Induction of Anaesthesia 3-4 mg/Kg • Drug of choice for cerebral protection • Sole anaesthetic agent for short less than 15 mins procedures • Treatment for raised ICP 3mg/Kg • For the control of convulsive states 3 mg/Kg • Narcoanalysis in psychiatric patients • IV maintenance 50-100mg every 10-12 mins Propofol Uses and Dosage • Induction of anaesthesia: 1.5 – 2.5 mg/kg, which needs to be reduced to 1-1.5 mg/kg in elderly patients. • Maintenance of anaesthesia: 100–300 μg/kg/min following an induction bolus. (Plasma concentrations of 2–6 μg/ml for surgery, with levels less than 1.5 μg/ml causing awakening). Various protocols including the Marsh Schneider and Minto, and Kataria protocol for paediatric populations are available for syringe pump administered TIVA, using a bolus elimination transfer dosing method based on two or three compartment models. • Conscious sedation: Loading dose of 0.5 to 1 mg/kg, followed by an infusion of 25 – 75 μg/kg/min. • Anti-emesis: Sub-hypnotic doses of Propofol (10 – 20 mg) may be used to treat PONV. • Treatment of status epilepticus (1 – 2 mg/Kg, followed by infusion). • Attenuation of bronchospasm.
Thiopentone ( Ref - Millers book of anaesthesia) Uses and Dosage • Induction of Anaesthesia 3-4 mg/Kg • Drug of choice for cerebral protection • Sole anaesthetic agent for short less than 15 mins procedures • Treatment for raised ICP 3mg/Kg • For the control of convulsive states 3 mg/Kg • Narcoanalysis in psychiatric patients • IV maintenance 50-100mg every 10-12 mins Propofol Uses and Dosage • Induction of anaesthesia: 1.5 – 2.5 mg/kg, which needs to be reduced to 1-1.5 mg/kg in elderly patients. • Maintenance of anaesthesia: 100–300 μg/kg/min following an induction bolus. (Plasma concentrations of 2–6 μg/ml for surgery, with levels less than 1.5 μg/ml causing awakening). Various protocols including the Marsh Schneider and Minto, and Kataria protocol for paediatric populations are available for syringe pump administered TIVA, using a bolus elimination transfer dosing method based on two or three compartment models. • Conscious sedation: Loading dose of 0.5 to 1 mg/kg, followed by an infusion of 25 – 75 μg/kg/min. • Anti-emesis: Sub-hypnotic doses of Propofol (10 – 20 mg) may be used to treat PONV. • Treatment of status epilepticus (1 – 2 mg/Kg, followed by infusion). • Attenuation of bronchospasm.